Think Gene - Latest Comments in I don’t want a 23andMe — I want the real genetic tests

Re: I don’t want a 23andMe — I want the real genetic tests

cags — Fri, 03 Oct 2008 22:13:39 -0000

Legally, any medical test must be ordered by a physician. What Brin did was not legal, and he really should not have done it outside of the context of a physician, particularly one with a genetics background. This is dangerous territory

Re: I don’t want a 23andMe — I want the real genetic tests

neandrothal — Mon, 22 Sep 2008 12:12:52 -0000

According to the Sherpa's own blog post (http://thegenesherpa.blogspot.com/2008/09/lrrk2...

"And even if you are Jewish, the penetrance of this mutation is 24 to 85%."

Sergey Brin is Jewish. Penetrance is defined as the probability of disease given the mutation. "24 to 85%" is completely consistent with Brin's 20-80% quote.

So Sergey's post is completely relevant. He has found out information about himself that according to studies *specific to his ethnicity* give him a 20-80% chance of getting Parkinson's, a dramatic increase above the <1% chance in the general population.

Re: I don’t want a 23andMe — I want the real genetic tests

drb — Sun, 21 Sep 2008 02:54:01 -0000

You really should be careful with referencing random blogs like that. They can claim anything. Sergey's post is quite clear about the penetrance. There is enough misinformation about genetics on the web already.

Re: I don’t want a 23andMe — I want the real genetic tests

helixhealth — Sat, 20 Sep 2008 22:30:38 -0000

Not really well established if you rely on the 3 papers which published different results and penetrance rates all over the place....

I am writing the authors of the gene tests article, b/c there is hype in it.

-Steve
www.thegenesherpa.blogspot.com

Re: I don’t want a 23andMe — I want the real genetic tests

helixhealth — Sat, 20 Sep 2008 21:42:23 -0000

Kevin, DId you read the paper or the abstract?
-Steve
www.thegenesherpa.blogspot.com

Re: I don’t want a 23andMe — I want the real genetic tests

saxonov — Sat, 20 Sep 2008 17:42:38 -0000

Yeah, the high penetrance is very well established. So there are many references.
For example, here is a pretty big paper that came out in July: http://www.ncbi.nlm.nih.gov/pubmed/18539534
Also, this is a good resource:
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?b...
(scroll down to penetrance).

Re: I don’t want a 23andMe — I want the real genetic tests

kevinfischer — Sat, 20 Sep 2008 16:25:31 -0000

Do you have a source for that? I was going off of Steve Murphy's post here: http://thegenesherpa.blogspot.com/2008/09/lrrk2...

Re: I don’t want a 23andMe — I want the real genetic tests

saxonov — Sat, 20 Sep 2008 14:12:53 -0000

One clarification re "I don’t particularly care about a mutation that gives me a slightly increased risk for a disease. " The increased risk is not slight.

This mutation is actually quite penetrant. It increases one's baseline risk by a factor of about 20, which is why Sergey said that his chances of developing PD are between 20 and 80%.

Re: I don’t want a 23andMe — I want the real genetic tests

Andrew Yates — Sat, 20 Sep 2008 00:08:26 -0000

You could probably do this, Kevin, if you had the technical ability, a PCR machine, and knew which primers to order...

Re: I don’t want a 23andMe — I want the real genetic tests

Kevin — Sat, 20 Sep 2008 00:02:43 -0000

"--" is automatically changed to an em dash in Wordpress -- that is quite possibly one of the best features I have ever seen in a program.