Think Gene - Latest Comments in Researchers pinpoint gene mutations responsible for 10 percent of schizophrenia

Re: Researchers pinpoint gene mutations responsible for 10 percent of schizophrenia

Florida Personal Injury Lawyer — Tue, 09 Feb 2010 11:55:33 -0000

either a gain or loss of genes, in 15 individuals diagnosed with schizophrenia that were not present in the chromosomes of either biological unaffected parent. Only two of such mutations were found in those without schizophrenia. Study subjects were from the European-origin Afrikaner population in South Africa, a genetically homogenous population that is ideal for genetic evaluation.

Re: Researchers pinpoint gene mutations responsible for 10 percent of schizophrenia

Andrew Yates — Sat, 31 May 2008 01:42:38 -0000

For such a heritable (40%) and research-targeted (NIMH $5MM pledged) disease , it's surprising that so little in the genome is known about schizophrenia. Here's a paper a month ago which suggests rare-variant "microdeletions and microduplications": Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia